The Intricate Connection Between Hand Physiology and Human Cognition

Exodux Nile
4 min readJul 12, 2023

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The human hand, a marvel of biological engineering, is a complex and sensitive organ composed of multiple muscle groups, various types of joints, and innervated by three different nerves. It comes as no surprise, then, that researchers are studying the intricate physiognomy of the hand to unravel the deepest mysteries of human cognition. Ever since Santiago Ramón y Cajal, the father of neuroscience, first revealed the complexity of the brain and its neural networks, scientists have tirelessly pursued the secrets of this vast organ. Even today, the brain’s functioning, connections, and surprising effects continue to astonish researchers. Consequently, neuroscientists, armed with years of knowledge about neuroplasticity, seek to develop a comprehensive theory on how the body can influence the mind.

[Neuroplasticity and Hand Function] Neuroplasticity refers to the brain’s remarkable ability to form and rewire its synaptic connections, enabling the establishment of more intricate neural networks. This adaptability proves especially useful following injuries to the body. Given the intimate relationship between the hand and the brain, where the brain tightly monitors and controls the hand’s intricate functions, it is plausible to consider that the reverse effect may also hold true. The diverse shapes of human hands possess specific measurements and indices that, according to Dr. Hubermann, can potentially influence cognitive functions. The natural androgens produced in the body may impact the developing brain of a child, leading to variations in hand indices with startlingly consistent effects observed among different populations.

[Hand Indices and Cognitive Differences] Numerous factors contribute to the observed cognitive differences associated with hand indices. Research published in Nature by Shungatogo highlights the ratio between the ring finger and index finger (2D:4D ratio) as a potential indicator for distinguishing individuals on the autistic spectrum from those who are not. Moreover, individual variations in hand anatomy can also significantly impact brain morphology and functioning.

In a study published in Nature in 2000, examining digit ratios in humans and the impact of androgens on prenatal development, it was revealed that testosterone exposure during this period tends to make the ring finger slightly shorter than the index finger in females. This finding has since been replicated multiple times. These subtle differences in finger lengths can hold profound implications for the structure and functioning of the brain.

[Hand Indices and Long-Term Cognition] The indices of the hand can have far-reaching consequences on long-term cognition, as demonstrated by the research conducted by Dr. Margaret Gatz and Dr. Christian Pike. Their study, involving a significant focus group of 8,000 Alzheimer’s disease patients, unveiled intriguing findings. Women with higher 2D:4D ratios, representing the female pattern of hand development, exhibited greater vulnerability to developing Alzheimer’s disease later in life.

Conversely, prenatal exposure to higher levels of androgens, resulting in the male pattern of hand development and lower 2D:4D ratios, appeared to preserve cognition for a more extended period among older women. To explore these effects, the researchers assessed cognitive functioning using three web-based tests: number series, picture vocabulary, and verbal analogies.

[Hand Functioning and Emotional Dispositions] Beyond cognitive differences, the human brain’s interconnection with the body extends to emotional functioning and behavior. Variations in hand shape and posture can be associated with distinct dispositions. Individuals with longer ring fingers than index fingers tend to exhibit a more logical thinking pattern and excel in problem-solving, often gravitating towards careers in science or engineering. Conversely, those with longer index fingers than ring fingers tend to be more solitary and goal-oriented, potentially indicating introverted tendencies. However, it’s important to note that these dispositions are not fixed, and individuals can possess intense personalities regardless of their hand shape. Hand posture, combined with the audio-visual processing involved in emotional functioning, can contribute to the diverse range of observations.

[Handwriting, Brain Development, and Reading Skills] Early learning of handwriting and the development of the brain’s “reading circuit” have significant implications for letter perception and reading skills. A study by Karen H. James, published in Trends in Neuroscience Education, revealed that early acquisition of these skills promotes a deeper understanding of letters and enhances reading abilities at a young age. This early development of specialized processing and interhemispheric connections in the brain can be facilitated by learning to write early on. Consequently, the repeated use and practice of motor functions, particularly those related to hand movements, can lead to observable changes in neuroimaging studies using MRI technology.

The human brain, intricately connected with the body, holds a wealth of information that can be discerned from our physical attributes. Among these, our hands provide surprisingly rich insights into our thoughts, emotions, and lifestyles. As researchers continue to delve into the complex relationship between hand physiology and human cognition, we gain a deeper understanding of ourselves and the interconnectedness of our minds and bodies.

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